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Alzheimer's Disease Cooperative Study Selected Research

4- ((3- (1,6- dihyro- 6- oxo- 9H- purin- 9- yl)- 1- oxopropyl)amino)benzoic acid

6/2003A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin) in mild Alzheimer's disease patients.
6/2002A phase I study of AIT-082 in healthy elderly volunteers.

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Alzheimer's Disease Cooperative Study Research Topics

Disease

15Alzheimer Disease (Alzheimer's Disease)
05/2017 - 06/2002
6Cognitive Dysfunction
09/2011 - 06/2003
5Dementia (Dementias)
05/2017 - 07/2005
2Atrophy
09/2011 - 06/2005
1Chills
05/2017
1Brain Edema (Cerebral Edema)
05/2017
1Respiratory Tract Infections (Respiratory Tract Infection)
05/2017
1Sleep Initiation and Maintenance Disorders (Insomnia)
11/2003
1Nervous System Diseases (Neurological Disorders)
06/2003
1Hypertension (High Blood Pressure)
06/2003
1Fatigue
06/2003
1Dizziness (Lightheadedness)
06/2003
1Body Weight (Weight, Body)
06/2002

Drug/Important Bio-Agent (IBA)

2Valproic Acid (Depakote)FDA LinkGeneric
09/2011 - 11/2005
2ApolipoproteinsIBA
09/2010 - 06/2005
2Vitamin EFDA LinkGeneric
09/2010 - 05/2007
2Apolipoproteins E (ApoE)IBA
09/2010 - 06/2005
2Pharmaceutical PreparationsIBA
05/2007 - 06/2003
24- ((3- (1,6- dihyro- 6- oxo- 9H- purin- 9- yl)- 1- oxopropyl)amino)benzoic acidIBA
06/2003 - 06/2002
1Amyloid (Amyloid Fibrils)IBA
05/2017
1Intravenous Immunoglobulins (IVIG)FDA Link
05/2017
1Biomarkers (Surrogate Marker)IBA
10/2015
1ResveratrolIBA
10/2015
1Receptor for Advanced Glycation End ProductsIBA
04/2014
1Cholinesterase Inhibitors (Anticholinesterases)IBA
04/2011
1huperzine AIBA
04/2011
1Donepezil (Aricept)FDA LinkGeneric
05/2007
1Apolipoprotein E4IBA
05/2007
1MelatoninIBA
11/2003
1purineIBA
06/2003
1rofecoxib (Vioxx)FDA Link
06/2003
1Naproxen (Naprosyn)FDA LinkGeneric
06/2003
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
06/2003
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
06/2003
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
06/2003

Therapy/Procedure

4Activities of Daily Living (ADL)
05/2017 - 07/2005
1Home Nursing (Nursing, Home)
11/2005